In this post, we will list down the major classifications of the antidepressant drugs and then explain important features about them.
Classification of Anti-Depressant Drugs
Anti depressants are classified in the following categories (with example drugs).
A – Tricyclics
- Neutral: Imipramine, Dothiepin
- Sedative: Amitriptyline, Trimipramine, Doxepin
- Stimulant: Desipramine, Nortriptyline, Protriptyline, Mianserin
B – heterocyclics
Amoxapine, Maprotiline, Trazodone, Bupropion, Venlafaxine
C – Monoamine Oxidase Inhibitors
- Hydrazide derivatives: Phenelzine, Isocarboxazid
- Non-hydrazide derivatives: Tranylcypromine, Moclobemide
D – Sympathomimetic Stimulants
Dextroamphetamine, Methylamphetamine, Methylphenidate
E – Selective Serotonini Reuptake Inhibitors
Fluoxetine, Paroxetine, Sertaline.
Details about different classes of antidepressants
Let’s see individual class of antidepressant drugs and what’s unique about them.
Their overdose / toxicity can cause:
- Respiratory depression
- Hyperpyrexia (very high fever, above 106.1 F)
- Prolonged QT interval
- Cardiotoxicity, Na+ channel inhibition leading to arrhythmia